Hesham Sadek, M.D.

J. Fred Schoellkopf, Jr. Chair in Cardiology

Internal Medicine - Cardiology
General Cardiology
Cardiac Imaging

Biography

Hesham A. Sadek, M.D., Ph.D., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center, where he also serves as the Associate Director of the Center for Regenerative Science and Medicine. He specializes in general cardiology and cardiac imaging.

Dr. Sadek earned his medical degree at Ain Shams University School of Medicine in Cairo, Egypt, and his doctoral degree in physiology and biophysics at Case Western Reserve University. He completed both his residency in internal medicine and fellowship in cardiology at University Hospitals Cleveland. He also performed a postdoctoral research fellowship in cardiology at UT Southwestern.

Certified by the American Board of Internal Medicine in cardiovascular diseases, he joined the UT Southwestern faculty in 2007.

Dr. Sadek’s research focus focuses on heart regeneration. Specifically, he and his team are interested in identifying methods to activate endogenous heart regeneration mechanisms in humans. He has delivered scores of presentations, published numerous academic articles, and contributed to books such as the fourth edition of Heart Failure: A Companion to Braunwald's Heart Disease. Dr. Sadek’s research is funded by grants from the NIH, AHA, CPRIT, and NASA among others.

He serves as Associate Editor of the journal Circulation and on the American Heart Association’s Scientific Sessions Planning Committee.

He’s a member of several professional organizations, including the American Medical Association, the American Heart Association, and the American College of Cardiology.

Among many other honors, in 2015 he received the AHA’s Established Investigator Award.

Professional Associations & Affiliations

American Medical Association
American Heart Association
American College of Cardiology
American Association for the Advancement of Science

Honors & Awards

J.Fred Schoellkopf, Jr. Chair in Cardiology 2015
American Society for Clinical Investigation 2015, UT Southwestern
Established Investigator Award 2015, American Heart Association
Douglas P.Zipes Distinguished Young Scientist Award 2013, American College of Cardiology
Research Scholars Program Cardiovascular Disease 2010, Gilead Sciences
Northwestern Cardiovascular Young Investigator Award 2008
Fellow-to-Faculty Transition Award 2007, American Heart Association
Research and Development Scholarship (Keystone) 2007, Pfizer
Young Investigator Award 2006, American Heart Association

Books & Publications

Books
- Cellular Basis for Myocardial Regeneration and Repair in Heart Failure: A Companion to Braunwald's Heart Disease
  Shah Ali, Nicholas Lam, and Hesham Sadek (2019), Elsevier
- Meis1 Regulates Postnatal Cardiomyocyte Cell Cycle Arrest in Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
  Shalini A. Muralidhar and Hesham A. Sadek (2016), Tokyo, Springer
- Metabolic characterization of hematopoietic stem cells in Hematopoietic Stem Cell Protocols
  Fatih Kocabas, Junke Zheng, Chengcheng Zhang, and Hesham A. Sadek (2014), Springer
- Endocarditis in Specialty Board Review Cardiology
  Hesham A. Sadek (2011), McGraw-Hill
Publications
- Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
  Ahmed MS, Wang P, Nguyen NUN, Nakada Y, Menendez-Montes I, Ismail M, Bachoo R, Henkemeyer M, Sadek HA, Kandil ES, Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 118 10
- Deep Learning Identifies Cardiomyocyte Nuclei With High Precision.
  Ali SR, Nguyen D, Wang B, Jiang S, Sadek HA, Circulation research 2020 Aug 127 5 696-698
- A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.
  Nguyen NUN, Canseco DC, Xiao F, Nakada Y, Li S, Lam NT, Muralidhar SA, Savla JJ, Hill JA, Le V, Zidan KA, El-Feky HW, Wang Z, Ahmed MS, Hubbi ME, Menendez-Montes I, Moon J, Ali SR, Le V, Villalobos E, Mohamed MS, Elhelaly WM, Thet S, Anene-Nzelu CG, Tan WLW, Foo RS, Meng X, Kanchwala M, Xing C, Roy J, Cyert MS, Rothermel BA, Sadek HA, Nature 2020 06 582 7811 271-276
- Homotypic Fusion Generates Multinucleated Cardiomyocytes in the Murine Heart.
  Ali SR, Menendez-Montes I, Warshaw J, Xiao F, Sadek HA, Circulation 2020 Jun 141 23 1940-1942
- Neonatal heart regeneration: Moving from phenomenology to regenerative medicine.
  Sadek HA, Porrello ER, The Journal of thoracic and cardiovascular surgery 2020 06 159 6 2451-2455
- Mechanism of Eccentric Cardiomyocyte Hypertrophy Secondary to Severe Mitral Regurgitation.
  Li S, Nguyen NUN, Xiao F, Menendez-Montes I, Nakada Y, Tan WLW, Anene-Nzelu CG, Foo RS, Thet S, Cardoso AC, Wang P, Elhelaly WM, Lam NT, Pereira AHM, Hill JA, Sadek HA, Circulation 2020 Jun 141 22 1787-1799
- Hypoxia Induces Cardiomyocyte Proliferation in Humans.
  Ahmed MS, Sadek HA, JACC. Basic to translational science 2020 May 5 5 461-462
- Mitochondrial Substrate Utilization Regulates Cardiomyocyte Cell Cycle Progression.
  Cardoso AC, Lam NT, Savla JJ, Nakada Y, Pereira AHM, Elnwasany A, Menendez-Montes I, Ensley EL, Petric UB, Sharma G, Sherry AD, Malloy CR, Khemtong C, Kinter MT, Tan WLW, Anene-Nzelu CG, Foo RS, Nguyen NUN, Li S, Ahmed MS, Elhelaly WM, Abdisalaam S, Asaithamby A, Xing C, Kanchwala M, Vale G, Eckert KM, Mitsche MA, McDonald JG, Hill JA, Huang L, Shaul PW, Szweda LI, Sadek HA, Nature metabolism 2020 02 2 2 167-178
- Toward the Goal of Human Heart Regeneration.
  Sadek H, Olson EN, Cell stem cell 2020 Jan 26 1 7-16
- Clinically-approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia.
  Borcherding DC, Siefert ME, Lin S, Brewington J, Sadek H, Clancy JP, Plafker SM, Ziady AG, The Journal of clinical investigation 2019 05 129 8 3448-3463
- Fibroblast Primary Cilia are Required for Cardiac Fibrosis.
  Villalobos E, Criollo A, Schiattarella GG, Altamirano F, French KM, May HI, Jiang N, Nguyen NUN, Romero D, Roa JC, García L, Diaz-Araya G, Morselli E, Ferdous A, Conway SJ, Sadek HA, Gillette TG, Lavandero S, Hill JA, Circulation 2019 Mar
- DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy.
  Nakada Y, Nhi Nguyen NU, Xiao F, Savla JJ, Lam NT, Abdisalaam S, Bhattacharya S, Mukherjee S, Asaithamby A, Gillette TG, Hill JA, Sadek HA, Circulation 2019 Feb 139 9 1237-1239
- C-Kit Cells Do Not Significantly Contribute to Cardiomyogenesis During Neonatal Heart Regeneration.
  Elhelaly WM, Cardoso AC, Pereira AHM, Elnawasany A, Ebrahimi S, Nakada Y, Sadek HA, Circulation 2019 Jan 139 4 559-561
- Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
  Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA, EMBO reports 2018 12 19 12
- Neonatal Heart Regeneration.
  Lam NT, Sadek HA, Circulation 2018 Jul 138 4 412-423
- The Effect of Hypoxia on Cardiovascular Disease: Friend or Foe?
  Savla JJ, Levine BD, Sadek HA High altitude medicine & biology 2018 Jun 19 2 124-130
- Hypoxia promotes primitive glycosaminoglycan-rich extracellular matrix composition in developing heart valves.
  Amofa D, Hulin A, Nakada Y, Sadek HA, Yutzey KE American journal of physiology. Heart and circulatory physiology 2017 Aug ajpheart.00209.2017
- Cardiomyocyte renewal in the human heart: insights from the fall-out.
  Lázár E, Sadek HA, Bergmann O European heart journal 2017 Aug 38 30 2333-2342
- Hypoxia Induced Myocardial Regeneration.
  Kimura W, Nakada Y, Sadek HA Journal of applied physiology (Bethesda, Md. : 1985) 2017 Aug jap.00328.2017
- Cardiomyocyte Regeneration: A Consensus Statement.
  Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser SR, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA Circulation 2017 Jul
- Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association.
  Hill JA, Ardehali R, Clarke KT, Del Zoppo GJ, Eckhardt LL, Griendling KK, Libby P, Roden DM, Sadek HA, Seidman CE, Vaughan DE Circulation research 2017 Jun
- Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.
  Mani RS, Amin MA, Li X, Kalyana-Sundaram S, Veeneman BA, Wang L, Ghosh A, Aslam A, Ramanand SG, Rabquer BJ, Kimura W, Tran M, Cao X, Roychowdhury S, Dhanasekaran SM, Palanisamy N, Sadek HA, Kapur P, Koch AE, Chinnaiyan AM Cell reports 2016 Dec 17 10 2620-2631
- Hypoxia induces heart regeneration in adult mice.
  Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah A, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Deberardinis R, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA Nature 2016 Oct
- Redox Regulation of Heart Regeneration: An Evolutionary Tradeoff.
  Elhelaly WM, Lam NT, Hamza M, Xia S, Sadek HA Frontiers in cell and developmental biology 2016 4 137
- Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
  Kimura W, Xiao F, Canseco DC, Muralidhar S, Thet S, Zhang HM, Abdulrahman Y, Chen R, Garcia JA, Shelton JM, Richardson JA, Ashour AM, Asaithamby A, Liang H, Xing C, Lu Z, Zhang CC, Sadek HA Nature 2015 Jun
- Redox signaling in cardiac renewal.
  Kimura W, Muralidhar S, Canseco DC, Puente B, Zhang CC, Xiao F, Abderrahman YH, Sadek HA Antioxidants & redox signaling 2014 Oct 21 11 1660-73
- Cardiomyocyte cell cycle: Meis-ing something?
  Mahmoud AI, Canseco D, Xiao F, Sadek HA Cell cycle (Georgetown, Tex.) 2014 Apr 13 7 1057-8
- The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response.
  Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA Cell 2014 Apr 157 3 565-79
- Surgical models for cardiac regeneration in neonatal mice.
  Mahmoud AI, Porrello ER, Kimura W, Olson EN, Sadek HA Nature protocols 2014 Feb 9 2 305-11
- Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.
  Zheng J, Lu Z, Kocabas F, Böttcher RT, Costell M, Kang X, Liu X, Deberardinis RJ, Wang Q, Chen GQ, Sadek H, Zhang CC Blood 2014 Feb 123 7 992-1001
- Hippo pathway effector Yap promotes cardiac regeneration.
  Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 110 34 13839-44
- Hypoxia and Metabolic Properties of Hematopoietic Stem Cells.
  Zhang CC, Sadek HA Antioxidants & redox signaling 2013 Jun
- Meis1 regulates postnatal cardiomyocyte cell cycle arrest.
  Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER, Sadek HA Nature 2013 Apr
- Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.
  Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, Mammen PP, Rothermel BA, Olson EN, Sadek HA Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 110 1 187-92
- Harnessing the power of dividing cardiomyocytes.
  Muralidhar SA, Mahmoud AI, Canseco D, Xiao F, Sadek HA Global cardiology science & practice 2013 2013 3 212-221
- Meis1 regulates the metabolic phenotype and oxidant defense of hematopoietic stem cells.
  Kocabas F, Zheng J, Thet S, Copeland NG, Jenkins NA, DeBerardinis RJ, Zhang C, Sadek HA Blood 2012 Dec 120 25 4963-72
- The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors.
  Kimura W, Sadek HA Cardiovascular diagnosis and therapy 2012 Dec 2 4 278-289
- The hypoxic epicardial and subepicardial microenvironment.
  Kocabas F, Mahmoud AI, Sosic D, Porrello ER, Chen R, Garcia JA, DeBerardinis RJ, Sadek HA Journal of cardiovascular translational research 2012 Oct 5 5 654-65
- Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model.
  Zang QS, Sadek H, Maass DL, Martinez B, Ma L, Kilgore JA, Williams NS, Frantz DE, Wigginton JG, Nwariaku FE, Wolf SE, Minei JP American journal of physiology. Heart and circulatory physiology 2012 May 302 9 H1847-59
- MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²? overload and cell death.
  Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, Humphries KM, Hill JA, Bassel-Duby R, Sadek HA, Olson EN The Journal of clinical investigation 2012 Apr 122 4 1222-32
- Transient Regenerative Potential of the Neonatal Mouse Heart
  Enzo R. Porrello, Ahmed I. Mahmoud, Emma Simpson, Joseph A. Hill, James A. Richardson, Eric N. Olson, and Hesham A. Sadek Science February 2011 25 February 2011: Vol. 33 no. 6020 pp. 1078-1080
- The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.
  Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. Cell Stem Cell September 2010 2010 Sep 3;7(3) 380-90
- Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.
  Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, Dimaio JM, Sadek H, Kuwahara K, Olson EN Circulation research 2010 Jul 107 2 294-304
- Bone-marrow-derived side population cells for myocardial regeneration.
  Sadek HA, Martin CM, Latif SS, Garry MG, Garry DJ Journal of cardiovascular translational research 2009 Jun 2 2 173-81
- Use of ferumoxides for stem cell labeling.
  Sadek H, Latif S, Collins R, Garry MG, Garry DJ, Regenerative medicine 2008 Nov 3 6 807-16
- Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells.
  Martin CM, Ferdous A, Gallardo T, Humphries C, Sadek H, Caprioli A, Garcia JA, Szweda LI, Garry MG, Garry DJ Circulation research 2008 May 102 9 1075-81
- Letter by Sadek and Garry regarding article, "Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium".
  Sadek HA, Garry DJ Circulation 2008 Apr 117 14 e306; author reply e307
- Cardiogenic small molecules that enhance myocardial repair by stem cells.
  Sadek H, Hannack B, Choe E, Wang J, Latif S, Garry MG, Garry DJ, Longgood J, Frantz DE, Olson EN, Hsieh J, Schneider JW Proceedings of the National Academy of Sciences of the United States of America 2008 Apr 105 16 6063-8
- Real time embolization of a mitral valve vegetation.
  Sadek HA, Hoit BD Echocardiography (Mount Kisco, N.Y.) 2007 Aug 24 7 768-9
- Images in cardiovascular medicine. Case of anomalous right superior vena cava.
  Sadek H, Gilkeson RC, Hoit BD, Brozovich FV, Circulation 2006 Oct 114 15 e532-3
- Inhibition of cardiac mitochondrial respiration by salicylic acid and acetylsalicylate.
  Nulton-Persson AC, Szweda LI, Sadek HA Journal of cardiovascular pharmacology 2004 Nov 44 5 591-5
- Modulation of mitochondrial complex I activity by reversible Ca2+ and NADH mediated superoxide anion dependent inhibition.
  Sadek HA, Szweda PA, Szweda LI Biochemistry 2004 Jul 43 26 8494-502
- Cardiac ischemia/reperfusion, aging, and redox-dependent alterations in mitochondrial function.
  Sadek HA, Nulton-Persson AC, Szweda PA, Szweda LI Archives of biochemistry and biophysics 2003 Dec 420 2 201-8
- Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion.
  Sadek HA, Humphries KM, Szweda PA, Szweda LI Archives of biochemistry and biophysics 2002 Oct 406 2 222-8
- Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion.
  Bulteau AL, Lundberg KC, Humphries KM, Sadek HA, Szweda PA, Friguet B, Szweda LI The Journal of biological chemistry 2001 Aug 276 32 30057-63