Depression Clinical Trials

Do you or a loved one struggle with mood swings? Or do you experience symptoms of mania or depression? If so, you may be a candidate for a clinical trial underway at UT Southwestern Medical Center. The following research trials are focused on investigating different treatments for depressive symptoms.

Transcranial Direct Current Stimulation (TDCS) Study

This is a controlled trial utilizing transcranial direct current stimulation to treat both unipolar depression and bipolar depression.

  • Inclusion Criteria: 18 years of age or above and a major depressive episode lasting at least four weeks   
  • Exclusion Criteria: Psychotic disorder, metal in the cranium, neurological disorder or insult, high suicide risk, pregnancy
  • Contact: Ankita Vora, M.D., 214-648-0401

Prolonging Remission in Depressed Elderly (PRIDE) Study

This clinical study is a National Institute of Mental Health (NIMH) sponsored multicenter trial investigation.

  • Inclusion Criteria: 60 years of age or older with major depressive disorder; Electroconvulsive Therapy (ECT) is clinically indicated
  • Exclusion Criteria: Dementia, delirium, schizophrenia, schizoaffective disorder, bipolar disorder
  • Contact: Najeeb Ranginwala, M.D., 214-648-2834

Preventing Perinatal Depression
(PRE-D) Study

The Pre-D study is designed to help develop tools to help women who are trying to conceive or are pregnant and who are at risk for depression to recognize, monitor, and respond to depressive symptoms.

  • Inclusion Criteria: Females 18 ­to 45 years old, who are actively attempting conception or are pregnant; at least one previous episode of DSM-IV diagnosis of major depressive disorder of four weeks duration; medically healthy according to structured medical history; under care of an Ob/Gyn or other health care provider; can provide informed consent
  • Exclusion Criteria: On birth control; meets criteria for current DSM-IV major depressive disorder and the HRSD-17 score is not less than or equal to 12 at diagnostic evaluation and randomization
  • Contact: Lauren Singer, 214-648-0176

Antidepressant Treatment for Asthma Outpatients Study

This is a 12-week study to determine if antidepressant treatment is associated with greater improvement in asthma and depression symptoms.

  • Inclusion Criteria: Adults age 18 to 70 who are currently receiving asthma treatment and experiencing symptoms of depression; English or Spanish speaking
  • Exclusion Criteria: Changes in asthma medications, oral corticosteroid use, or respiratory infection treatment in the past two weeks
  • Contact: Domingo Davila, 214-645-6963

Lurasidone for Bipolar I Disorder Study

This is a 12-week clinical trial researching the effects of Lurasidone on mood symptoms in bipolar I disorder patients. The study involves open-label lurasidone treatment.

  • Inclusion Criteria: Diagnosed with bipolar I disorder
  • Exclusion Criteria: Pregnant, nursing, or planning to become pregnant
  • Contact: Claire Gardner, 214-645-6953

EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care) Study

This is a clinical trial sponsored by the National Institute of Mental Health (NIMH) to find biomarkers that will improve the treatment of depression. 

  • Inclusion Criteria: 18 to 65 years of age and chronic or recurrent major depressive episodes   
  • Exclusion Criteria: Psychotic or bipolar disorder, metal in the cranium, high suicide risk, pregnancy
  • Contact: Aasia Ali, 214-648-0829 or 214-648-HELP (214-648-4357)