Therapeutic

A randomized, phase III, multicenter, double-blind, placebo-contolled study of evaluating the efficacy and safety of Onartuzumab (MetMAb) in combination with Tarceva (erlotinib) in patients with MET diagnostic-positive non-small cell lung cancer (NSCLC) who have received standard chemotherapy for advanced or metastatic disease.

A PHASE III RANDOMIZED TRIAL OF LOBECTOMY VERSUS SUBLOBAR RESECTION FOR SMALL (≤ 2 CM) PERIPHERAL NON-SMALL CELL LUNG CANCER

A Phase 1-2 trial of MM-121 in Combination with Erlotinib in Three Groups of Patients with Non-Small Cell Lung Cancer

A Phase 1/2A Therapeutic, Open Label, Multi-Center Clinical Trial of NPC-1C, a Chimeric Monoclonal Antibody in Adults with Recurrent, Locally Advanced Unresectable or Metastatic Pancreatic and Colorectal Cancer after Standard Therapy

A Phase 2 Randomized Open-label Study of Erlotinib plus Tivantinib (ARQ 197) versus Single Agent Chemotherapy in Previously Treated KRAS Mutation Positive Subjects with Locally Advanced or Metastatic Non–Small Cell Lung Cancer

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GS-6624 Combined with FOLFIRI as Second Line Treatment for Metastatic KRAS Mutant Colorectal Adenocarcinoma that Has Progressed Following a First Line Oxaliplatin- and Fluoropyrimidine-Containing Regimen.

A Phase 2, Multi-center, open-label, randomized, parallel-group study of a lenalidomide (Revlimid) regimen or A sequential Azacitidine (Vidaza) plus Lenalidomide (Revlimid) regimen versus an Azacitidine (Vidaza) regimen for therapy of older subjects with newly diagnosed acute myeloid leukemia

A Phase 2, Open-Label, Multicenter Study of PSMA ADC in Subjects with Metastatic Castration Resistant Prostate Cancer (mCRPC)

A Phase 2, Randomized, Open-Label Study of the Safety and Efficacy of Two Doses of Quizartinib (AC220; ASP2689) in Subjects with FLT3-ITD Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)

A Phase 3, Multicenter, Randomized, Open-label Study to Compare the Efficacy and Safety of Pomalidomide (POM), Bortezomib (BTZ) and Low-Dose Dexamethasone (LD-DEX) versus Bortezomib and Low-Dose Dexamethasone in Subjects with Relapsed or Refractory Multiple Myeloma (MM)

A Phase 3, Randomized, Controlled, Double-Blind, Multinational Clinical Study of the Efficacy and Safety of Vosaroxin and Cytarabine versus Placebo and Cytarabine in Patients with First Relapsed or Refractory Acute Myeloid Leukemia (VALOR)

A Phase 3, Randomized, Open Label Trial of Lenalidomide/dexamethasone With or Without Elotuzumab in Relapsed or Refractory Multiple Myeloma

A Phase I Study of Cyberknife® Partial Breast Irradiation (PBI) for Early Stage Breast Cancer

A Phase I Study of the Phosphatidylserine-Targeting Antibody Bavituximab in Combination with Capecitabine and Radiation Therapy for the Treatment of Stage II and III Rectal Adenocarcinoma

A Phase I dose escalation study of ARQ 761 (Beta-Lapachone) in adult patients with advanced solid tumors

A Phase I open-label study of the safety and pharmacokinetics of escalating doses of DNIB0600A in patients with non-small cell lung cancer and platinum-resistant ovarian cancer

A Phase I, Multicenter Study of MRX34 Given Intravenously Two Times per Week for Three Weeks, Repeated Every Four Weeks in Patients with Unresectable Primary Liver Cancer or Advanced or Metastatic Cancer With Liver Involvement

A Phase I/II Study of Bavituximab and Sorafenib In Patients With Advanced Hepatocellular Carcinoma

A Phase I/II Study of Erlotinib and Romidepsin in Advanced Non-Small Cell Lung Cancer

A Phase II Multi-Center Study of Concomitant Cetuximab and Cisplatin with Re-Irradiation using Intensity-Modulated Radiotherapy in Patients with Recurrent Squamous Cell Carcinoma of the Head-and-Neck

A Phase II Randomized Trial of Paclitaxel, Carboplatin, Bevacizumab with or without IMC-A12 in Patients with Advanced Non-Squamous, Non-Small Cell Lung Cancer

A Phase II Study of Crenolanib Besylate in Subjects with Relapsed Acute Myeloid Leukemia with FLT3-D835 Activating Mutations

A Phase II Study of Pioglitazone for patients with cancer of the pancreas

A Phase II Study of Valproic Acid and Radiation, Followed by Maintenance Valproic Acid and Bevacizumab in Children with Newly Diagnosed High-Grade Gliomas or Brainstem Gliomas

A Phase II Trial of Erlotinib (Tarceva®) in Combination with Stereotactic Body Radiation Therapy (SBRT) for Patients with Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC)

A Phase II Trial of Response Adapted Therapy of Stage III-lV Hodgkin Lymphoma Using Early Interim FDG-PET Imaging.

A Phase II, Multicenter, Single-arm Study of Oral LDK378 in Crizotinib naïve Adult Patients With ALK-activated Non-small Cell Lung Cancer

A Phase II, Randomized, Open Label, Parallel Arm Study to Evaluate the Safety and Efficacy of rAd-IFN/Syn3 Following Intravesical Administration in Subjects with High Grade, BCG Refractory Relapsed Non-Muscle Invasive Bladder Cancer (NMIBC)

A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma in Situ Resected by Lumpectomy (NSABP B-43)

A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy versus High-Dose Interferon Alfa-2b for Resected High-risk Melanoma

A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients With Completely Resected Stage IB (> 4 cm) -IIIA Non-Small Cell Lung Cancer (NSCLC)

A Phase III Study of Chemotherapy and Chemoradiotherapy With or Without HyperAcute®-Pancreas Immunotherapy in Subjects with Surgically Resected Pancreatic Cancer

A Phase III Surgical Trial to Evaluate the Benefit of a Standard versus an Extended Pelvic Lymphadenectomy Performed at Time of Radical Cystectomy for Muscle Invasive Urothelial Cancer

A Phase III, Double-Blind, Randomized, Placebo-Controlled, Multicenter Clinical Trial to Study the Safety, Tolerability, Efficacy, and Immunogenicity of V212 in Recipients of Autologous Hematopoietic Cell Transplants (HCTs)

A Phase III, Multi-Center, Randomized, Controlled Study to Assess the Efficacy and Safety of ON 01910.Na Administered as a 72-Hour Continuous Intravenous Infusion Every Other Week in Myelodysplastic Syndrome Patients with Excess Blasts Relapsing After, or Refractory to, or Intolerant to Azacitidine or Decitabine

A RANDOMIZED PHASE I/II STUDY OF NAB-PACLITAXEL, OR PACLITAXEL, PLUS CARBOPLATIN WITH CONCURRENT RADIATION THERAPY FOLLWED BY CONSOLIDATION IN PATIENTS WITH FAVORABLE PROGNOSIS INOPERABLE STAGE IIIA/B NON-SMALL CELL LUNG CANCER (NSCLC)

A Randomized Controlled Study of YONDELIS (Trabectedin) or Dacarbazine for the Treatment of Advanced Liposarcoma or Leiomyosarcoma Previously Treated with an Anthracycline and Ifosfamide

A Randomized Phase 2 Study of the Efficacy and Tolerability of Veliparib in Combination with Temozolomide or Veliparib in Combination with Carboplatin and Paclitaxel Versus Placebo plus Carboplatin and Paclitaxel in Subjects with BRCA 1 or BRCA 2 Mutation and Metastatic Breast Cancer (M12-895)

A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel ) to Chemotherapy Plus Trastuzumab in Women with Node Positive or High Risk Node Negative HER 2 Low Invasive Breast Cancer. NSABP B 47

A Randomized Phase III Trial of the value of early local therapy for the intact primary tumor in patients with metastatic breast cancer

A Randomized, Double-Blind, Multi-Center Phase 3 Study of ADI-PEG 20 Plus Best Supportive Care (BSC) Versus Placebo Plus BSC in Subjects With Advanced Hepatocellular Carcinoma (HCC) Who Have Failed Prior Systemic Therapy

A Randomized, Double-Blind, Placebo Controlled, Phase II Study of BKM120 Plus Paclitaxel in Patients with HER2 Negative Inoperable Locally advanced or Metastatic Breast Cancer, With or without P13K Pathway Activation

A Randomized, Multicenter, Phase 3 Study Comparing Carfilzomib, Lenalidomide, and Dexamethasone (CRd) vs Lenalidomide and Dexamethasone (Rd) in Subjects with Relapsed Multiple Myeloma

A Randomized, Open-Label Phase 2 Study of EC145 Single-agent and the Combination of EC145 plus Docetaxel Versus Docetaxel Alone in Participants with Folate-Receptor Positive [FR(++)] Second Line NSCLC

A Study to Evaluate the Efficacy and Safety of Dinaciclib or Ofatumumab in Subjects with Refractory Chronic Lymphocytic Leukemia (CLL)

A Trial of Single Autologous Transplant with or without Consolidation Therapy versus Tandem Autologous Transplant with Lenalidomide Maintenance for Patients with Multiple Myeloma

A phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study of the efficacy and safety of lenalidomide (Revlimid®) as maintenance therapy for patients with B-cell chronic lymphocytic leukemia following second-line therapy

A phase I/II study of nab-paclitaxel, cisplatin and cetuximab with concurrent radiation therapy for local-regionally advanced head-and-neck squamous cell carcinoma

A phase II, multicenter, single-arm study of oral LDK378 in adult patients with ALK-activated non-small cell lung cancer previously treated with chemotherapy and crizotinib

A phase III randomized, double blind, placebo controlled study of BKM120 with fulvestrant, in postmenopausal women with hormone receptor-positive HER2-negative AI treated, locally advanced or metastatic breast cancer who progressed on or after mTOR inhibitor based treatment-(BKM 120-2303)

A randomized Phase III, double-blind, placebo-controlled multicenter trial of daily everolimus in combination with trastuzumab and vinorelbine, in pretreated women with HER2/neu over-expressing locally advanced or metastatic breast cancer

A randomized, double-blind, multicenter, Phase III study of everolimus (RAD001) plus best supportive care versus placebo plus best supportive care in the treatment of patients with advanced NET of GI or lung origin - RADIANT-4

AALL0433, Intensive Treatment for Intermediate-Risk Relapse of Childhood B-Precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies

AALL0434: Intensified Methotrexate, Nelarabine (Compound 506U78; IND# 52611) and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-cell Acute Lymphoblastic Leukemia

AALL0631: A Phase III Study of Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition(CEP-701, Lestaurtinib; IND#76431; NSC#617807)

AALL07P1, A Phase II Pilot Trial of Bortezomib (PS-341, Velcade, IND# 58,443) in Combination with Intensive Re-Induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL) A Groupwide Pilot Study

AALL0932, Treatment of Patients with Newly Diagnosed Standard Risk B-Lymphoblastic Leukemia (B-ALL) or Localized B-lineage Lymphoblastic Lymphoma (B-LLy)

AALL1121, A Single-Arm Multicenter Phase II Study preceded by Dose Evaluation to Investigate the Efficacy, Safety, and Tolerability of the BiTE®Antibody Blinatumomab (MT103) in Pediatric and Adolescent Patients with Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)

AALL1122, A Phase 2 Multi-Center Historically - Controlled Study of Dasatinib Added to Standard Chemotherapy in Pediatric Patients with Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)

AALL1131, A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum

AAML05P1, Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Cell Transplantation (HCT) for Refractory and Relapsed Acute Myelogenous Leukemia (AML) and Newly Diagnosed AML with Monosomy 7 or -5/5q- in Children

AAML1031, A Phase III Randomized Trial for Patients with de novo AML using Bortezomib and Sorafenib (IND#114480; NSC# 681239, NSC# 724772) for Patients with High Allelic Ratio FLT3/ITD

ACCL0922, (SCUSF 0901) A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor

ACCL0933, A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)

ACCL0934, A Randomized Trial of Levofloxacin to Prevent Bacteremia in Children Being Treated for Acute Leukemia (AL) or Undergoing Hematopoietic Stem Cell Transplantation (HSCT)

ACNS0331: A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18 Gy) and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial

ACNS0332, Efficacy of Carboplatin administered Concomitantly with Radiation and Isotretinoin as a Prop-Apoptotic Agent in Other Than Average Risk Medulloblastoma/PNET Patients.

ACNS0821, Temozolomide with Irinotecan Versus Temozolomide, Irinotecan plus Bevacizumab for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial

ACNS1021, A Phase II Study of Sunitinib (NSC# 736511, IND# 74019) in Recurrent, Refractory or Progressive High Grade Glioma and Ependymoma Tumors in Pediatric and Young Adult Patients

ACNS1022, A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas

ACNS1123, Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors

ACOSOG Z11102 Impact of Breast Conservation Surgery on Surgical Outcomes and Cosmesis in Patients with Multiple Ipsilateral Breast Cancers (MIBC)

ADVL0912, A Phase 1/2 Study of PF-02341066, an Oral Small Molecule Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-MET, in Children with Relapsed/Refractory Solid Tumors and Anaplastic Large Cell Lymphoma

ADVL0918, A Phase 1 Study of Temsirolimus in Combination with Irinotecan and Temozolomide in Children, Adolescents, and Young Adults with Relapsed or Refractory Solid Tumors

ADVL0921, A Phase II Study of MLN8237 (IND# 102984), a Selective Aurora A Kinase Inhibitor in Children with Recurrent/Refractory Solid Tumors and Leukemias

ADVL1011, A Phase 1 Study of JAK Inhibition (INCB018424) in Children with Relapsed or Refractory Solid Tumors, Leukemias, and Myeloproliferative Neoplasms

ADVL1014, A Phase 1 Dose Escalation Study of REOLYSIN, a Replication Competent Reovirus, in Pediatric Patients with Relapsed or Refractory Solid Tumors

ADVL1112, A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children with Refractory or Recurrent Solid Tumors and Lymphomas

ADVL1121, A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib (IND# 69896) in Children and Young Adults with Relapsed/Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma

ADVL1221, A Phase II Study of Cixutumumab (IMC-A12; IND# 100947) in Combination with Temsirolimus (IND# 61010) in Pediatric Patients with Recurrent or Refractory Solid Tumors

AEWS0331: European Ewing Tumor Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99)

AEWS1031, A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma

AHEP0731, Treatment of Children with All Stages of Hepatoblastoma

AN INTERGROUP PHASE II CLINICAL TRIAL FOR ADOLESCENTS AND YOUNG ADULTS WITH UNTREATED ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF INOTUZUMAB OZOGAMICIN ADMINISTERED IN COMBINATION WITH RITUXIMAB COMPARED TO DEFINED INVESTIGATORS CHOICE THERAPY IN SUBJECTS WITH RELAPSED OR REFRACTORY CD22-POSITIVE AGGRESSIVE NON-HODGKIN LYMPHOMA WHO ARE NOT CANDIDATES FOR INTENSIVE HIGH-DOSE CHEMOTHERAPY

ANBL0032: Phase III Randomized Study of Chimeric Antibody 14.18 (Ch 14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue

ANBL09P1, A COG Pilot Study of Intensive Induction Chemotherapy and 131I-MIBG/ Irinotecan/Vincristine Followed by Myeloablative Busulfan-Melphalan (Bu-Mel) for Newly Diagnosed High-Risk Neuroblastoma

ARAR0331: Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy

ARAR0332, Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy

AREN0321, Treatment of High Risk Renal Tumors

AREN0532, Treatment for Very Low, Low and Standard Risk Favorable Histology Wilms Tumor

AREN0533: Treatment of Newly Diagnosed Higher Risk Favorable Histology Wilms Tumors

AREN0534, Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor

ARET0321, A Trial of Intensive Multi-Modality Therapy for Extra-Ocular Retinoblastoma

ARST0531- Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS)

ARST08P1, A Pilot Study to Evaluate Novel Agents (Temozolomide and Cixutumumab [IMC-A12, Anti-IGF-IR Monoclonal Antibody, IND #100947, NSC #742460]) in Combination with Intensive Multi-Agent Interval Compressed Therapy for Patients with High-Risk Rhabdomyosarcoma

ARST0921, A Randomized Phase II Trial of Bevacizumab (IND# 7921, Avastin) and Temsirolimus (IND# 61010, Torisel) in Combination with Intravenous Vinorelbine and Cyclophosphamide in Patients with Recurrent/Refractory Rhabdomyosarcoma

An Open Label, Multicenter, Randomized, Phase III Study of S-1 and Cisplatin Compared with 5-FU and Cisplatin in patient with metastatic Diffuse Gastric Cancer Previously Untreated with Chemotherapy

An Open-Label, Multicenter, Randomized Phase 2 Study Evaluating the Safety and Efficacy of Ramucirumab (IMC 1121B) Drug Product or IMC 18F1 in Combination With Capecitabine or Capecitabine Monotherapy, in Unresectable, Locally Advanced or Metastatic Breast Cancer Patients Previously Treated With Anthracycline and Taxane Therapy

An Open-Label, Randomized, Phase 2 Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Patients with Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma

An Open-Label, Single-Arm Multicenter Phase 2 Study of E7080 in Subjects With Advanced Endometrial Cancer and Disease Progression Following First-Line Chemotherapy

An Open-label Randomized Phase III Trial of BMS-936558 versus Docetaxel in Previously Treated Advanced or Metastatic Squamous Cell Non-small Cell Lung Cancer (NSCLC)

An Open-label, Multicenter Study of the Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Opioid Experienced Children from Ages 6 to 16 Years Old, Inclusive, with Moderate to Severe Malignant and/or Nonmalignant Pain Requiring Opioid Analgesics

An open label randomized phase III trial of BMS-936558 versus docetaxel in previously treated metastatic non-squamous cell non-small cell lung cancer (NSCLC).

An open label two-stage study of orally administered BKM120 in patients with metastatic non-small cell lung cancer with activated PI3K pathway

CALGB 30610/RTOG 0538: Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

CALGB 80803-Randomized Phase II Trial of PET Scan-Directed Combined Modality Therapy in Esophageal Cancer

CALGB C80702- A PHASE III TRIAL OF 6 VERSUS 12 TREATMENTS OF ADJUVANT FOLFOX PLUS CELECOXIB OR PLACEBO FOR PATIENTS WITH RESECTED STAGE III COLON CANCER

Dose Escalating Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) for Patients with Hepatic Metastases

E1A10: A Randomized Phase I/II study of Bortezomib, Rituximab, Dexamethasone and Temsirolimus in Patients with Relapsed Waldenstrom's Macroglobulinemia and Relapsed/Refractory Mantle Cell Lymphoma or Follicular Lymphoma (Phase I), and Untreated/Relapsed Waldenstrom's Macroglobulinemia (Phase II)

E2511: Phase I and Randomized Phase II Double Blind Clinical Trial of Cisplatin and Etoposide in Combination With Veliparib (ABT-888) or Placebo as Frontline Therapy for Extensive Stage Small Cell Lung Cancer

E2809: Androgen Receptor Modulation: A Phase II randomized study of MK-2206 - Bicalutamide combination in patients with rising PSA at high-risk of progression after primary therapy

E3F05 Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas

E6508: A Phase II Study of L-BLP25 and Bevacizumab in Unresectable Stage IIIA and IIIB Non-Squamous Non-Small Cell Lung Cancer after Definitive Chemoradiation

ECOG 3108 : A Phase II Prospective Trial Correlating Progression Free Survival with CYP2D6 Activity in Patients with Metastatic Breast Cancer Treated with Single Agent Tamoxifen

GOG 0244: The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors and Impact in Newly Diagnosed Patients

GOG 0254: A Phase II Evaluation of SU11248 (Sunitinib Malate) (IND# 74019, NSC# 736511) in the Treatment of Persistent or Recurrent Clear Cell Ovarian Carcinoma

GOG 0277- A Phase III Randomized Trial of Gemcitabine (NSC# 613327) plus Docetaxel (NSC# 628503) followed by Doxorubicin (NSC# 123127) v. observation for uterus-limited, High Grade Uterine Leiomyosarcoma

GOG 0724: Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-stage Cervical Carcinoma Following Radical Hysterectomy

GOG 212: A Randomized Phase III Trial of maintenance chemotherapy comparing 12, monthly cycles of single agent Paclitaxel or Xyotax (CT-2103) (IND# 70177), versus no treatment until documented relapse in women with advanced Ovarian or primary Peritonel cancer who achieve a complete clinical response to primary Platinum/Taxane Chemotherapy

GOG 229K: A Phase II Evaluation of BIBF 1120 (IND#113086) in the Treatment of Recurrent or Persistent Endometrial Carcinoma

GOG 238: A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-only Recurrence of Carcinoma of the Uterine Corpus

GOG 240: A Randomized Phase III Trial of Cisplatin Plus Paclitaxel With and Without NCI-Supplied Bevacizumab (NSC #704865, IND #113912) Versus the Non-Platinum Doublet, Topotecan Plus Paclitaxel, With and Without NCI-Supplied Bevacizumab, In Stage IVB, Recurrent or Persistent Carcinoma of the Cervix

GOG 241: A GCIG Intergroup Mulitcenter Phase III Trial of Open Label Carboplatin and Paclitaxel +/- Bevacizumab Compared with Oxaliplatin and Capecitabine +/- Bevacizumab as First Line Chemotherapy in Patients with Mucinous Epithelial Ovarian Cancer

GOG 258: A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma

GOG 261: A Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Ifosfamide Plus Paclitaxel in Chemotherapy-Naïve Patients with Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus, Fallopian Tube, Peritoneum, or Ovary

GOG 262/ACRIN 6695: A Phase III Trial of Every-3-Weeks Paclitaxel Versus Dose Dense Weekly Paclitaxel in Combination with Carboplatin with or without Concurrent and Consolidation Bevacizumab (NSC 704865, IND #7921, 113912) in the Treatment of Primary Stage II, III or IV Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer and ACRIN 6695: Perfusion CT Imaging to Evaluate Treatment Response in Patients Participating in GOG-0262

GOG 263: Randomized Phase III Clinical Trial of Adjuvant Radiation versus Chemoradiation in Intermediate Risk, Stage I/IIA Cervical Cancer Treated with Initial Radical Hysterectomy and Pelvic Lymphadenectomy

GOG 264: A Randomized Phase II Trial of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex Cord-Stromal Tumors of the Ovary

GOG 274: A PHASE III TRIAL OF ADJUVANT CHEMOTHERAPY AS PRIMARY TREATMENT FOR LOCALLY ADVANCED CERVICAL CANCER COMPARED TO CHEMORADIATION ALONE: THE OUTBACK TRIAL (ANZGOG 0902/GOG-0274/RTOG 1174)

GOG-0076HH: A Phase I/II Trial of Paclitaxel, Cisplatin and CTEP Supplied Agent ABT-888 (IND#77840, NSC#737664) in the Treatment of Advanced, Persistent, or Recurrent Carcinoma of the Cervix

GOG-0127W: A Phase II Evaluation of ABT-888 (IND#77840, NSC #737664), Topotecan (NSC #609699) and Filgrastim or Pegfilgrastim in the Treatment of Persistent or Recurrent Squamous or Non-Squamos Cell Carcinoma of the Cervix

M10-897 A Randomized, Double-Blind, Phase 2, Dose-Ranging Study to Evaluate the Safety and Efficacy of Veliparib and Whole Brain Radiation Therapy Versus Placebo and Whole Brain Radiation Therapy in Subjects with Brain Metastases from Non-Small Cell Lung Cancer

PBMTC ONC-032P, High dose temozolomide, thiotepa and carboplatin with autologous stem cell rescue (ASCR) followed by continuation therapy with 13-cis-retinoic acid in patients with recurrent/refractory malignant brain tumors

PHASE II STUDY OF NEOADJUVANT LETROZOLE FOR POSTMENOPAUSAL WOMEN WITH ESTROGEN RECEPTOR POSITIVE DUCTAL CARCINOMA IN SITU (DCIS) CALGB 40903

PRESENT: Prevention of Recurrence in Early-Stage, Node-Positive Breast Cancer with Low to Intermediate HER2 Expression with NeuVax™ Treatment

Phase 3, Randomized, Open-Label Study of the Efficacy and Safety of Crizotinib Versus Pemetrexed/Cisplatin or Pemetrexed/Carboplatin in Previously Untreated Patients with Non-Squamous Carcinoma of the Lung Harboring a Translocation or Inversion Event Involving the Anaplastic Lymphoma Kinsase (ALK) Gene Locus

Phase I Study of An Autologous Idiotype Vaccine Manufactured by magnICON® Technology for the Treatment of Patients with Follicular Lymphoma in First Relapse/Progression

Phase I/II Trial of Fenretinide/LXS oral powder (NSC 374551) plus Ketoconazole in Recurrent Ovarian Cancer, Fallopian Tubes and Primary Peritoneal Carcinoma

Phase II Trial of Hippocampal-Avoiding Whole Brain Irradiation with Simultaneous Integrated Boost for Treatment of Brain Metastases

Phase II Trial of Molecularly Determined Treatment of Children and Young Adults with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas

Phase III Randomized Study of Standard versus Accelerated Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients with Stage II-III Non-Small Cell Lung Cancer and Poor Performance Status

RTOG 0813: Seamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients

RTOG 1005: A Phase III Trial of Accelerated Whole Breast Irradiation with Hypofractionation plus Concurrent Boost Versus Standard Whole Breast Irradiation plus Sequential Boost for Early-Stage Breast Cancer

RTOG 1008 A RANDOMIZED PHASE II STUDY OF ADJUVANT CONCURRENT RADIATION AND CHEMOTHERAPY VERSUS RADIATION ALONE IN RESECTED HIGH-RISK MALIGNANT SALIVARY GLAND TUMORS

RTOG 1010 A PHASE III TRIAL EVALUATING THE ADDITION OF TRASTUZUMAB TO TRIMODALITY TREATMENT OF HER2-OVEREXPRESSING ESOPHAGEAL ADENOCARCINOMA

RTOG 1014: A Phase II Study of Repeat Breast Preserving Surgery and 3D-Conformal Partial Breast Re-Irradiation (PBRI) For Local Recurrence of Breast Carcinoma

RTOG 1115 Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT)with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 for Men with High Risk Prostate Cancer

RTOG 3501 TRYHARD: A PHASE II, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY OF LAPATINIB (TYKERB®) FOR NON-HPV LOCALLY ADVANCED HEAD AND NECK CANCER WITH CONCURRENT CHEMORADIATION

RTOG 534 A Phase III Trial Of Short Term Androgen Deprivation With Pelvic Lymph Node Or Prostate Bed Only Radiotherapy (SPPORT) In Prostate Cancer Patients With A Rising PSA After Radical Prostatectomy

RTOG 631 Phase II/III study of image-guided radiosurgery/SBRT for localized spine metastasis

RTOG 815 PHASE III PROSPECTIVE RANDOMIZED TRIAL OF DOSE-ESCALATED RADIOTHERAPY WITH OR WITHOUT SHORT-TERM ANDROGEN DEPRIVATION THERAPY FOR PATIENTS WITH INTERMEDIATE-RISK PROSTATE CANCER

RTOG 920 A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer

RTOG 937: Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer (ED-SCLC)

Randomized Phase II Trial of Adjuvant Combined Epigenetic Therapy with 5-Azacitidine and Entinostat in Resected Stage I Non-Small Cell Lung Cancer Versus Standard Care

Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study of Denosumab as Adjuvant Treatment for Women with Early-Stage Breast Cancer at High Risk of Recurrence (D-CARE)

Risk-Adapted Therapy for Young Children with Embryonal Brain Tumors, High-Grade Glioma, Choroid Plexus Carcinoma or Ependymoma (SJYC07)

S1007: A Phase III Randomized Clinical Trail of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2 Negative Breast Cancer with recurrence Score (RS) of 25 or less

SBRT Spine: Phase II Study of Stereotactic Body Radiation Therapy and Vertebroplasty for Localized Spinal Metastasis

T2009-012, A Phase I Dose Finding Study Of Panobinostat In Children With Refractory Hematologic Malignancies

Therapy Targeting the Interleukin-3 Receptor (IL3R) for Patients with Relapsed or Refractory and Elderly Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) with DT388IL3 (SL-401) (IND# 11314): a Phase IB Clinical Trial

Prevention

CALGB 70806- Vitamin D and Breast Cancer Biomarkers

Dallas Cancer Disparities Community Coalition: Breast Cancer Prevention Education Program II

NSABP P5 Statin Polyp Prevention Trial in Patients with Resected Colon Cancer

Supportive Care

392MD44/C, An open-label, cross-over, pharmacokinetic study to assess the safety and pharmacokinetics of transdermal granisetron (Sancuso® patch) and IV granisetron in a pediatric oncology population (aged 13 to 17 years)

A Phase III Randomized, Placebo-Controlled, Clinical Trial to Study the Safety and Efficacy of V212 in Adult Patients with Solid Tumor or Hematologic Malignancy

A Randomized Controlled Study of Extracorporeal Photopheresis (ECP) Therapy with UVADEXTM for the Treatment of Patients with Moderate to Severe Chronic Graft-versus-Host Disease (cGvHD)

A Randomized, Double Blind, Dose Finding, Placebo-Controlled, Phase II Multicenter Study of Tetrodotoxin in the Treatment of Chemotherapy Induced Neuropathic Pain.

A randomized, prospective, double blind, placebocontrolled, phase 3 study of US-ATG-F prophylaxis as a supplement to standard of care prophylaxis to prevent moderate to severe chronic GVHD in adult acute myeloid leukemia, acute lymphoid leukemia, and myelodysplastic syndrome patients after allogeneic stem cell transplantation from unrelated donors

BTTC11-01: Randomized, double-blind, placebo-controlled trial of lacosamide for seizure prophylaxis in patients with High-Grade Gliomas

Defibrotide for Patients with Hepatic Veno-Occlusive Disease (VOD): A Treatment IND Study (Under CFR 312.34)

Role of Commensal Microbial Flora in Acute Intestinal Graft Versus Host Disease

The Management and Outcome of Uterine Cancer

Screening/Early Detection/Diagnostic

A Randomized Trial of Surveillance of Low-Grade Non-Invasive Bladder Cancer Using Standard Follow-Up Versus Cystoscopy and NMP22 BladderChek Test

Advanced MR Imaging Techniques in the Characterization of Renal Cell Carcinoma: Correlation with Pathology and Gene Expression Profiles

An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection

Banking of Tissue and Establishing Continuous Cell Lines and Xenografts From Neoplasia (South Plains Oncology Consortium Bank [SPOC])

Factors associated with adolescent HPV vaccine use in UTSW and Parkland affiliated clinics

Genetic Determinants of Keloid Formation Study

Prospective, Longitudinal, Multinational Registry of Patients with Newly Diagnosed Peripheral T-Cell Lymphoma

Technology Development for Intracellular Metabolites at 7 Tesla

The relationship between Breslow depth and lateral spread of melanoma using histological and immunohistochemical analyses

Epidemiological/Observational/Outcome

9442: National Wilms Tumor Late Effects Study

A Multicenter Study of Hematopoietic Stem Cell Donor Safety and Quality of Life

ACCL1033, A Comprehensive Approach to Improve Medication Adherence in Pediatric ALL

AEWS07B1, A COG Study for Collecting and Banking Ewing Sarcoma Specimens

ALTE03N1: Key Adverse Events Following Childhood Cancer

ALTE05N1, Umbrella Long-Term Follow-up Protocol

ALTE07C1, Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with Cancer

An Inter-Personal Framework for Lung Cancer Decision-Making in African Americans

An analysis of the association between sociodemographic factors and delays to cancer treatment

Ancillary Laboratory Protocol for the Collection of Diagnostic Material on Patients Considered for ECOG Treatment Trials for Leukemia or Related Hematologic Disorders

Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer

Breast Cancer Rehabilitation Improving Daily Function and Participation

Breast Screening & Patient Navigation (BSPAN2): Evaluating a De-Centralized Regional Delivery System for Rural Underserved

CancerGene Connect

Childhood Cancer Survivor Study Expansion: Long-Term Follow-up Study

Comparing Outcomes after Cystectomy based on status of molecular markers

Comprehensive Gynecologic Oncology Tissue and Blood Sample Repository

Coping with Cancer II

Evaluating Fatigue and Hope in Pediatric Hematopoietic Stem Cell Transplantation Recipients

Evaluation of Radiation-Induced Vasculopathy by Transcranial Doppler (TCD) Among Survivors of Childhood Medulloblastoma Treated with Cranial Radiation Therapy

Evaluation of System Enhancements for Magnetic Resonance Imaging Hardware and Software in a Clinical Setting

Evaluation of microRNAs as novel markers of cardiotoxicity in children undergoing anthracycline therapy for pediatric cancer

Facilitating Risk-Appropriate Colorectal Cancer Testing - Testing the Cancer Risk Intake System (CRIS)

Follow-Up study of breast health outcomes and selected biomarkers in women at high risk for breast cancer: The Serial Evaluation of Ductual Epithelium (SEDE) Clinical Trial

Fort Worth Program for Community Survivorship (ProComS)

H-29892, Case Ascertainment for Epidemiologic Studies of Childhood Cancers

Health related quality of life in patients with Hepatocellular Carcinoma(HCC).

Identification and description of low testosterone among male patients treated with crizotinib

Impact of Attitudes Toward Lung Cancer

Long-term Follow-up of Patients Enrolled on Pediatric Oncology Group-sponsored Research

Lung Specimen Banking Program

MTX Neurotoxicity in Children with ALL

Metabolic Syndrome, Cardiovascular Risk and Insulin Resistance in Pediatric Survivors of Brain Tumors Treated with Radiation

Molecular Genetic Changes of Ovarian Cancer

Molecular Mechanisms Involved in Cancer Predisposition

Neural Mechanisms of Tyrosine Kinase Inhibitor-Induced Hypertension in Humans

Parkland-UT Southwestern PROSPR Center

Parkland-UT Southwestern PROSPR Center: Colon cancer screening in a safety net: Organizational & patient factors influencing guideline-based CRC screening

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

Participation in Registry, Research Database, and Research Sample Repository for Patients Undergoing Hematopoietic Cell Transplantation or Cellular Therapies

Pathways between Socioeconomic Status and Behavioral Cancer Risk Factors

Patient, Provider, & Institutional Effects on Latinos

Predictors and impact of MyChart use among patients treated at an NCI-designated cancer center

Prognostic significance of circulating tumor cells in patients with Renal Cell Carcinoma

Prospective Database of Clinical Characteristics and Outcomes For Surgical Oncology Patients

Prospective Research Assessment in Multiple Myeloma: An Observational Evaluation (PREAMBLE)

Prospective randomized study on cancer patients to assess the impact of consent length on patients accrual rate and comprehension to obtain tumor tissues for UTSW Tissue Resource.

Quality of Life (QoL) after Hypofractionated Radiation in the Treatment of Patients with Cancer

Quality of Life in Adolescent and Young Adult Testicular Cancer Survivors

Resection of skull base tumors involving facial nerve: Results after immediate nerve grafting

Retrospective Chart Review of Lung Cancer Patients from 2000 to 2008

Risk Factor Analysis of Hereditary Breast and Ovarian Cancer

Sentinel Lymph Node Working Group Data Acquisition Project

Standardizing creatinine clearance estimation for the Calvert formula to improve the safety and efficacy of carboplatin

Strategic Timing of AntiRetroviral Treatment (START)

Surveillance for low-risk non-muscle invasive bladder cancer: A Pilot Study

The Management and Outcome of Gestational Trophoblastic Disease

The Management and Outcome of Invasive/In Situ Cervical Carcinoma

The University of Texas Southwestern Medical Center Tissue Resource (UTSTR)

The influence of a cancer diagnosis on smoking cessation efforts and outcomes

Tissue Procurement and Outcome Collection for Radiotherapy Treated Patients

Transfusional Iron Overload in Children Treated for Cancer

Ancillary

AADM0211: Permission for Screening Tests for Participation in Children's Oncology Group Developmental Therapeutics/Phase I Consortium Clinical Research Protocols

ACCRN07, Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network (CCRN)

AREN03B2: Renal Tumors Classification, Biology and Banking

E3A05: Ancillary Laboratory Protocol for Collecting Diagnostic Material on Patients Considered for Studies of Multiple Myeloma and Other Plasma Cell Disorders

Correlative

A Multicenter Access And Distribution Protocol For Unlicensed Cryopreserved Cord Blood Units (CBUs) For Transplantation In Pediatric And Adult Patients With Hematologic Malignancies And Other Indications

AALL05B1: A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

AALL08B1, Classification of Newly Diagnosed Acute Lymphoblastic Leukemia

AAML08B1, Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS)

AHOD04B1, Hodgkin Disease (HD) Banking Study

ANBL00B1: Neuroblastoma Biology Studies

AOST06B1, A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

An Analysis of Genomic and Molecular Profiles of Lung Cancer for the Prediction of Response to Therapy and Clinical Outcomes

D9902, A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol

Epigenetic Testing for Breast Cancer Risk Stratification

Expression of co-inhibitory receptors in inflammatory skin disease

Impact of Body weight on the pharmacokinetic analysis of Doxorubicin and Cyclophosphamide in Breast Cancer Patients

Kidney Cancer New Pathway Discovery Project

Lung Cancer Mutation Consortium Protocol

Molecular Characteristics of Tumor Cells

National Marrow Donor Program (NMDP)- Consent for Participation and Donation of Blood Samples

OVA1® Post Marketing Surveillance Study PS110001

Personalized Genetic History and Triple Negative Breast Cancer

Predicting Treatment Response for Cervical Cancer: Assessment Using BOLD MRI

Role of Commensal Flora in the Development of Bacteremia and Fungemia in Cancer And Stem Cell Transplant Patients

Studies of daily anatomic change and tumor position for adaptive radiation therapy

Tissue Procurement and Outcome Collection for Patients with Hematologic Malignancies

Diagnostic

A Clinical, non-intervention study of the Cxbladder® urine test for the detection of recurrent urinary tract Urothelial Carcinoma (UC)

Other

Analysis of Morphogenic Effect of hDAB21P on Prostate Cancer and its Disease Correlation

Retrospective Records Review

Clinical-Pathologic Predictors of Tumor Response, Survival, and Toxicity in Patients with Rectal Adenocarcinoma Undergoing Trimodality Therapy

Other

Establishment of Urologic Tissue and Serum Repository

Diagnostic

Feasibility Study using Imaging Biomarkers in Lung Cancer

Screening

Feasibility of CT Perfusion (CTP) as a noninvasive method for characterizing pulmonary lesions as benign or malignant: Comparison of CTP findings with histopathology and other imaging results.

Other

Hepatocellular carcinoma Early Detection Strategy study (HEDS)

Diagnostic

High Resolution Magnetic Resonance Imaging in Patients with Brain Tumors

Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Other

National Oncologic PET Registry

Retrospective Records Review

Once-Weekly intravenous liposomal amphotericin B (AmBisome) for fungal prophylaxis in pediatric high-risk hematologic malignancy: A retrospective evaluation of safety and tolerability

Other

Procurement of Patient Tissue Samples to Facilitate the Study of Disorders of Mineral Metabolism

Registries/Repository

Registry Study to Evaluate the Clinical Outcomes of Cancer Patients and Benigh Diseases Treated With Radiation at the University of Texas Southwestern Medical Center

Other

Retrospective Chart Review of Renal Cell Carcinoma patients treated from 1/1/2000 to 3/1/2012

Retrospective Records Review

Retrospective Chart Review of outcomes in patients with glioma treated 1/1/2000-5/1/2012

Screening

Screening for Bladder Cancer

Other

The Role of CAR and its Application in Bladder Cancer

Retrospective Records Review

The incidence and significance of a prior cancer diagnosis among patients with lung cancer

Screening

Use of the CA-125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women