Testicular Cancer

Testicular cancer can occur in one or both testicles, the pair of male reproductive organs that produces sperm and male hormones. Nearly 9,000 new cases of testicular cancer are diagnosed in the United States each year. While about half of the cases affect men who are 20 to 34 years old, the disease can strike males of all ages.

The team at UT Southwestern Harold C. Simmons Comprehensive Cancer Center provides advanced, comprehensive care to men with testicular cancer. We work in multidisciplinary teams to strategically and compassionately provide the latest treatment options and help men maintain their quality of life.


Germ-cell tumors make up more than 90 percent of testicular cancer cases. The two types of germ-cell tumors – seminomas and nonseminomas – occur with about equal prevalence.

Stromal tumors – Leydig cell tumors and Sertoli cell tumors – comprise about 5 percent of testicular cancers.

While rare, secondary testicular cancer – cancer that has spread to a testicle from another organ – most commonly develops due to cancer of the lymphatic system (lymphoma).

Risk Factors

Risk factors for testicular cancer include:

  • Undescended testicle(s) (orchiopexy)
  • Family history of testicular cancer
  • Human immunodeficiency virus (HIV)
  • Cancer in the other testicle
  • Carcinoma in situ, abnormal cells that can be precancerous


Not all cases of testicular cancer cause symptoms. Among men who do experience symptoms, the most common are:

  • A lump, swelling, or tenderness in a testicle
  • A change in the consistency or shape of a testicle

Men experiencing symptoms that could indicate testicular cancer should see their doctors.


Whether through self-examination or during a physical exam, when an abnormality is discovered that suggests testicular cancer, physicians may order blood work, a tissue sample, or imaging studies – mostly commonly ultrasound – to make a diagnosis.


Treatment for testicular cancer depends on its characteristics and stage, as well as on the patient's overall health, preferences, and goals. Treatment options include:

Clinical Trials

UT Southwestern offers clinical trials that may provide you with an opportunity to complement traditional therapy for genitourinary cancer with the newest, most promising treatment strategies. Talk with your doctor to determine if a clinical trial is right for you.

Meet the Team

Our testicular cancer specialists include:

See all of our specialists who treat testicular cancer and other genitourinary cancers.

Request an Appointment

To schedule an appointment with a testicular cancer specialist, request an appointment or call 214-645-8300.