Endometrial Cancer

Endometrial cancer – sometimes called uterine cancer – begins in the layer of cells that form the lining (endometrium) of the uterus. It is the most common cancer of the female reproductive tract. About one-third of ovarian cancer cases are believed to begin as endometrial cancer.

UT Southwestern Harold C. Simmons Comprehensive Cancer Center has extensive experience with this difficult cancer. Our gynecologic oncologists treat some of the most complex cases of endometrial cancer, offering minimally invasive surgery, fertility-sparing treatment, radiation therapy, chemotherapy, and hormone therapy.

Types of Endometrial Cancer

Nearly all endometrial cancers are endometrial adenocarcinomas, which originate from glandular tissue. Subtypes of endometrial adenocarcinomas include adenosquamous carcinomas, papillary serous adenocarcinomas, and clear cell carcinomas.

Uterine sarcoma, the other main type of endometrial cancer, originates in the connective tissue or muscle of the uterus.

Gestational trophoblastic disease is a rare condition in which tumors grow inside a woman’s uterus when she is pregnant.


To diagnose endometrial cancer, your doctor may perform a physical exam, order blood work, take a tissue sample, or call for additional testing if you have symptoms or if the disease is suspected for other reasons.

At UT Southwestern, we use a wide range of oncology imaging techniques to diagnose, treat, and monitor patients with endometrial cancer. These include:

  • Transvaginal ultrasound or sonography
  • Staging and operating endoscopy
  • Computed tomography (CT)
  • Magnetic resonance imaging (MRI)
  • Positron emission tomography (PET)


Treatment for endometrial cancer depends on its characteristics and stage, your overall health, and your preferences and goals. Options include:

When endometrial cancer is detected early, removing the uterus, fallopian tubes, and ovaries often eliminates all of it. We may also remove the pelvic lymph nodes. Using the latest advancements in surgical technologies and tools UT Southwestern offers a growing number of minimally invasive and laparoscopic techniques for surgically treating endometrial cancer in appropriate patients.
Learn more about surgery for gynecologic cancer.
Radiation therapy
This variety of treatments includes external-beam radiation and internal radiation therapy, or brachytherapy.
Learn more about radiation therapy for gynecologic cancer.
Our treatments include the most advanced combinations of cancer-killing drugs.
Research at UT Southwestern has found that a mutation in a single gene can cause endometrial cancer that is responsive to a specific drug therapy. Eventually it may be possible to screen women with endometrial cancer to see if their cancer will respond to chemotherapy. More testing is underway.

Learn more about medical treatments for gynecologic cancer.

Hormone therapy
This treatment, which often but not always involves progesterone, can slow the growth of endometrial cancer cells that have receptors to the hormone on them. Hormone therapy may also be used in combination with other types of treatment or, for women who cannot have surgery or radiation therapy, in lieu of other treatments.

Women with endometrial cancer may have concerns about if and how treatment may affect their sexual function and fertility. Our experts will discuss all options with you before treatment begins, and you should not be afraid to ask questions.

Meet Our Experts

Our team of endometrial cancer experts includes:

Learn more about all members of our gynecologic cancer team.

Clinical Trials

Many patients qualify to participate in the gynecologic cancer-related clinical trials conducted at UT Southwestern to gain access to new treatments and to further research of the disease.

Learn about endometrial cancer clinical trials offered at UT Southwestern.

Request an Appointment

To schedule an appointment with an endometrial cancer specialist, request an appointment or call 214-645-8300.