Quantitative Magnetic Resonance Imaging (qMRI) for the Physiological Characterization of Tumors in the Lung

Study ID
STU 062013-028

Study Sites

  • UT Southwestern Moncrieff Cancer Center

Contact
Michael Fulkerson
214/648-5984
Michael.Fulkerson@UTSouthwestern.edu

Principal Investigator
Fernando Kay, M.D.

Summary

This protocol is an initial feasibility study for the use of Quantitative Magnetic Resonance imaging (MRi) Techniques to characterize the physiology of tumors in the lung. These techniques include oxygen-enhanced (oe) MRi, Diffusion Weighted imaging (DWi), arterial Spin Labeling (aSL), and Dynamic Contrast-enhanced (DCe) MRi. as a first step, it is essential to confirm that the oe MRi techniques, useful in other tumors/cancers (as noted below) as a surrogate for hypoxia, will have measureable effects in tumors in the lung. This is being done as part of a developing research strategy between basic science investigators at uTSW and the stereotactic body radiation therapy clinical team. This is part of investigations for a developing program project grant application in the department of radiation oncology.

We propose to image up to 45 patients with the Quantitative MRi techniques to determine if the derived data is consistent in nature with data obtained in other anatomic sites. it is possible that the unique tissue densities in the lung will create artifacts that change the nature of this data. as such, it is not appropriate to assume that these techniques will be feasible in the lung.

Participant Eligibility

Male and female subjects age >= 18 years.
Histological confirmation of a tumor in the lung.


* Patients must have gross untreated tumor within their chest visible on CT or MRI.

Pretreatment Evaluations Required for Eligibility include:
A medical history.
Mandatory imaging studies:
-CT or MRI scan of the chest (preferably with intravenous contrast, unless medically contraindicated) delineating the extent of the tumor.
Mandatory laboratory studies: Must be done 30 or fewer days prior to study entry
-Estimated GFR (must be >=45 mL/min/1.73m2) calculated from serum creatinine.
-Women between the ages of 18-50 who have not had a hysterectomy or bilateral oophorectomy; or have been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceeding 12 consecutive months) will have a urine pregnancy test completed the day of their scheduled MRI.
Patient must provide study-specific consent prior to study entry.
Patient must be scheduled to receive SBRT for his/her tumor in the lung.